Networks in MS

The interconnections between cells and systems is increasingly recognized in multiple sclerosis which is a complex disease. The goal of this forum is to provide an update on the current state of knowledge regarding cellular, molecular and social networks in MS.

+ Thursday, February 27, 2020

9:45 - 11:00am Charcot Symposium

11:15am - 1:45pm NAIMS/IMSVISUAL Symposium
2:00 - 2:10pm Opening Address
Jeffrey Cohen, Cleveland Clinic
Tanuja Chitnis, Brigham & Woman's Hospital, Harvard; Alexandre Prat, Université de Montréal
2:10 - 3:20pm Kenneth P. Johnson Memorial Lecture
Peter Calabresi, Johns Hopkins Medicine
3:20 - 3:50pm Break
3:50 - 5:10pm SESSION 1 - Emerging Concepts in MS
Chairs: Fiona Costello, University of Calgary; Myla Goldman, University of Virginia; Adil Harroud, McGill University

Theme: Highlighting cutting edge studies that inform our understanding of the pathogenic mechanisms in MS, introduce novel measures to capture disease activity, and advance treatment options for affected individuals. This session will be comprised of platform presentations by Young Investigators selected from submitted abstracts. There will be eight 10 minute talks, each consisting of eight minute presentations and two minute Q&A.
3:50 - 4:00pm Young Investigator 1
4:00 - 4:10pm Young Investigator 2
4:10 - 4:20pm Young Investigator 3
4:20 - 4:30pm Young Investigator 4
4:30 - 4:40pm Young Investigator 5
4:40 - 4:50pm Young Investigator 6
4:50 - 5:00pm Young Investigator 7
5:00 - 5:10pm Young Investigator 8
5:15 - 6:00pm National Multiple Sclerosis Society (NMSS) Barancik Award Presentation and Talk
6:00 - 8:00pm Poster Session 1 / Opening Networking Event

+ Friday, February 28, 2020

7:00 - 8:15am Industry Sponsored Satellite Symposium
8:00 - 8:30am Breakfast
8:30 - 10:55am SESSION 2 - Precision Medicine for MS
Chairs: Philip De Jager, Columbia University; Nathalie Arbour, University of Montreal; Brooke Rhead, UC Berkley

Theme: Precision diagnostic tools are utilized in several areas of medicine and lessons learned may be applied to MS. There are emerging biomarkers distinguishing MS from similarly appearing diseases. Imaging and molecular biomarkers that distinguish MS from other diseases will further enhance diagnostic criteria.
8:30 - 8:35am Opening Comments by Session Chairs
8:35 - 9:00am Network theory as it applies to MS
Sergio Baranzini, University of California - San Francisco
9:00 - 9:25am Systems biology approaches for MS
Dan Geschwing, Geffen School of Medicine, UCLA
9:25 - 9:55am Break
9:55 - 10:20am Data-mining for predicting therapeutic response in MS
Bibi Bielekova, NIH
10:20 - 10:45am Social Networks in MS and Related Diseases
Amar Dhand, Brigham and Women's Hospital
10:45 - 10:55am Panel Discussion
11:00am - 1:00pm Poster Session 2 / Lunch
1:00 - 3:45pm SESSION 3 - Immune Celle Networks in MS
Chairs: Ben Segal, University of Michigan/Ohio State; Gregory Wu, Washington University at St. Louis; Anne-Katrin Probstel, University of California - San Francisco

Theme: There are emerging pathological, genetic and immunological biomarkers including antigen specific responses that characterize and differentiate MS from other similar neuroimmunological diseases.
1:00 - 1:05pm Opening Comments by Session Chairs
1:05 - 1:30pm Lymphocyte-myeloid cell networks in MS
Estelle Betelli, University of Washington
1:30 - 1:55pm Imaging of the immune cell-endothelial cell networks in MS
Dorian McGavern, NIH
1:55 - 2:25pm Break
2:25 - 2:50pm Lymphocyte-meningeal mediated CNS inflammation in MS
Zsuzsanna Fabry, University of Wisconsin-Madison
2:50 - 3:15pm Review of the impact of current therapeutics on immune cell networks
Frauke Zipp, Mainz
3:15 - 3:25pm Panel Discussion
3:30 - 3:45pm Break
3:45 - 5:15pm Cutting Edge Developments
Chairs: Tiffany Braley, University of Michigan; Susan Gauthier, Cornell; Manu Rangachari, University of Laval
3:45 - 4:00pm Microbiome and immune analysis in AQP4 NMO
Scott Zamvil, University of California - San Francisco
4:00 - 4:15pm Immune analyses in MOG-related disorders
Chitnis Lab Member
4:15 - 5:15pm Ground Breaking Abstract from submitted material
4:15 - 4:25pm Ground Breaking Presentation 1
4:25 - 4:35pm Ground Breaking Presentation 2
4:35 - 4:45pm Ground Breaking Presentation 3
4:45 - 4:55pm Ground Breaking Presentation 4
4:55 - 5:05pm Ground Breaking Presentation 5
5:05 - 5:15pm Ground Breaking Presentation 6
5:30 - 6:30pm Awards Reception
6:45 - 8:00pm Industry Supported Satellite Symposium
6:45 - 9:00pm Resident Summit Dinner
8:00 - 10:00pm Social Event TBD

+ Saturday, February 29, 2020

6:30 - 7:45am Industry Supported CME Satellite Symposium

7:00 - 8:00am Breakfast
8:00 - 9:55am SESSION 4 - CNS Cellular networks in MS Endophenotypes
Chairs: V. Wee Yong, University of Calgary; Catherine Larochelle, University of Montreal; Christen Evonuk, Cleveland Clinic

8:00 - 8:05am Opening Comments by Session Chairs
8:05 - 8:30am Microglia-cytokine axis to modulate synaptic connectivity: potential applications to MS
Dorothy Schafer, University of Massachusetts Medical School
8:30 - 8:55am Neuronal and glial cell imaging in MS
Tarun Singhal, Brigham and Women's Hospital
8:55 - 9:20am Glial cell-neuron communication and influence
Martin Kerchensteiner, Munich
9:20 - 9:45am Glial cell related therapeutics
Jerold Chun, Scripps Institute
9:45 - 9:50am Panel Discussion
10:00 - 10:15am Break
10:15am - 12:10pm SESSION 5 - Neural-anatomical Networks
Chairs: Daniel Reich, NIH; Maria Rocca, Milan; Christina Azevedo, USC

10:15 - 10:20am Opening Comments by Session Chairs
10:20 - 10:45am Neuronal hubs in MS
Eric Klawiter, Harvard, MGH
10:45 - 11:10am fMRI correlates of cognitive dysfunction in MS
Nancy Sicotte, Cedars Sinai
11:10 - 11:35am Imaging biomarkers of remyelination and repair
Jiwon Oh, University of Toronto
11:35am - 12:00pm Imaging of Neural Plasticity in MS
Peter Stys, University of Calgary
12:00 - 12:10pm Panel Discussion
12:15 - 1:35pm Lunch
12:15 - 1:30pm Resident Summit Lunch
12:20 - 1:35pm Industry Supported Satallite Symposium

1:45 - 3:505pm SESSION 6 - Microbial networks and interactions iwth the CNS
Chairs: Emmanuelle Waubant, University of California – San Francisco; Stephanie Tankou, Mount Sinai NYC; Marc Charabati, University of Montreal

1:45 - 1:50pm Opening Comments by Session Chairs
1:50 - 2:15pm Microbiota networks in the gut, lung and skin
Helen Tremlett, University of British Columbia
2:15 - 2:40pm Microbiota and immune system networks in the periphery
Jennifer Gommerman, University of Toronto
2:40 - 3:05pm Potential for microbiome as a therapeutic target
Howard Weiner, Harvard Medical School
3:05 - 3:30pm Caloric restriction and dietary interventions in MS
Ellen Mowry, Johns Hopkins
3:30 - 3:40pm Panel Discussion
3:40 - 3:50pm Closing Remarks
Jeffrey Cohen, Cleveland Clinic
4:00 - 5:15pm Industry Supported Satellite Symposium

Independent Industry Supported CME Satellite Symposia are not included in the formal ACTRIMS Forum 2020 accredited program.

**Independent Industry Supported non-CME Product Theaters are not included in the formal ACTRIMS Forum 2020 accredited program.

+ IMSVISUAL Symposium

Thursday, February 28, 2019
12:30 - 1:45pm

Chaired by Laura Balcer, NYU Langone Health and Elena Martínez-Laspiscina, Hospital Clínic de Barcelona

12:30-12:45pm Is there progressive retinal damage in neuromyelitis optica spectrum disorders?
Friedemann Paul, NeuroCure Clinical Research Center
12:45-1:00pm Smartphone Suite of Visual Tests in Multiple Sclerosis
Randy Kardon, University of Iowa Health Care
1:00-1:15pm Corneal Confocal Microscopy: "A rapid non-invasive technique to image neurodegeneration"
Ioannis Petropoulos, Weill Cornell Medicine - Qatar
1:15-1:30pm Dynamics of retinal layer atrophy in normal aging and multiple sclerosis
Elias Sotirchos, Johns Hopkins University
1:30-1:45pm Retinal imaging in EAE for translational neuroprotection studies
Philipp Albrecht, Heinrich-Heine-Universität Düsseldorf

+ NAIMS Symposium

Friday, March 1, 2019
7:00 - 8:15 am

The Central Vein Sign in Multiple Sclerosis: Update and Future DirectionsModerated by Nancy Sicotte

7:00 - 7:15am Imaging the Central Vein Sign: Overview of current MRI techniques
Pascal Sati, National Institutes of Health
7:15 - 7:30am Detection of the Central Vein Sign: Specificity and Sensitivity
Andrew Solomon, University of Vermont
7:30 - 8:00am Abstract Presentations
Mário João Fartaria
Jordan Dworkin
Suradech Suthiphosuwan

8:00 - 8:15am Central Vein in the Clinic: Next Steps
Daniel Ontaneda, Cleveland Clinic