Thursday, February 28, 2019

12:30 - 1:45pm IMSVISUAL Symposium
2:00 - 2:10pm Opening Address
Jack Antel, McGill University
Alexandre Prat, Université de Montréal, and Tanuja Chitnis, Brigham & Woman's Hospital, Harvard
2:10 - 3:30pm SESSION 1 - Emerging Concepts in MS
Chairs: Catherine Larochelle, Université de Montreal; Ben Segal, University of Michigan

Theme: Highlighting cutting edge studies that inform our understanding of the pathogenic mechanisms in MS, introduce novel measures to capture disease activity, and advance treatment options for affected individuals. This session will be comprised of platform presentations by Young Investigators selected from submitted abstracts. There will be eight 10 minute talks, each consisting of eight minute presentations and two minute Q&A.
2:10 - 2:20pm The "Central Vein Sign" in Inflammatory Demyelination: The Role of Fibrillar Collagen Type I
Martina Absinta
2:20 - 2:30pm Accelerated Cord Atrophy Precedes Conversion to Secondary Progressive Disease in Relapsing Multiple Sclerosis
Antje Bischof, University of California, San Francisco
2:30 - 2:40pm NLRX1 Inhibits Early Stages of CNS Inflammation and Prevents the Onset of EAE
Marjan Gharagozloo, University of Sherbrooke
2:40 - 2:50pm Parental Imprinting of X Chromosome Genes: Effects on Autoimmunity
Lisa Golden, University of California, Los Angeles
2:50 - 3:00pm Leukocyte Telomere Length is Associated with Disability Progression in Multiple Sclerosis Independent of Chronological Age
Kristen Krysko, University of California, San Francisco
3:00 - 3:10pm Cerebrospinal Fluid Biomarkers Link Toxic Astrogliosis and Microglial Activation to Multiple Sclerosis Severity
Ruturaj Masvekar, NIAID/NIH
3:10 - 3:20pm Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation Via IL10
Olga Rojas, University of Toronto
3:20 - 3:30pm Single-Cell Genomics Reveals Spatial and Stage-Associated Diversity in Multiple Sclerosis
Lucas Schirmer, University of Heidelberg
3:30 - 4:00pm Break
4:00 - 5:15pm Kenneth P. Johnson Memorial Lecture
Rhonda Voskuhl, University of California, Los Angeles
5:15 - 6:00pm National Multiple Sclerosis Society (NMSS) Barancik Award Presentation and Talk
6:00 - 8:00pm Poster Session 1 / Opening Networking Event

Friday, March 1, 2019

7:00 - 8:15am NAIMS Symposium
8:30 - 11:15am SESSION 2 - Precision Medicine for MS
Chairs: Tanuja Chitnis, Brigham & Woman's Hospital, Harvard; Alexandre Prat, Université de Montréal

Theme: Precision diagnostic tools are utilized in several areas of medicine and lessons learned may be applied to MS. There are emerging biomarkers distinguishing MS from similarly appearing diseases. Imaging and molecular biomarkers that distinguish MS from other diseases will further enhance diagnostic criteria.
8:30 - 8:40am Opening Comments by Session Chairs
8:40 - 9:05am From Basic Science to Precision Medicine in Oncology: Lessons Learned and a Guide for MS
John DeGroot, MD Anderson
9:05 - 9:30am From Basic Science to Precision Medicine in Rheumatology: Lessons Learned and a Guide for MS
Timothy Niewold, New York University
9:30 - 10:00am Break
10:00 - 10:25am Precision Medicine in the MS Clinic: Current State and New Biological Tools
Gavin Giovannoni, Blizard Institute
10:25 - 10:50am Precision Medicine in the MS Clinic: Selecting the Right Patient for the Right Treatment
Mark Freedman, University of Ottawa
10:50 - 11:15am Panel Discussion
11:15am - 1:00pm Poster Session 2 / Lunch
1:00 - 3:45pm SESSION 3 - Precision Diagnosis of MS
Chairs: Jiwon Oh, University of Toronto; Phil De Jager, Columbia University

Theme: There are emerging pathological, genetic and immunological biomarkers including antigen specific responses that characterize and differentiate MS from other similar neuroimmunological diseases.
1:00 - 1:10pm Opening Comments by Session Chairs
1:10 - 1:35pm Genetic and Gene Expression Signatures for MS Diagnosis
Nikolaos Patsopoulos, Brigham and Women's Hospital, Harvard
1:35 - 2:00pm Can the B Cell and T Cell Profiles Be Used for Precision Diagnosis and Treatment of Demyelinating Diseases?
Jeffrey Bennett, University of Colorado
2:00 - 2:30pm Break
2:30 - 2:55pm Spectrum of MS Disease Course (Mild, Severe, MSSS)
Ilya Kister, New York University
2:55 - 3:20pm New Imaging Approaches for Precision Diagnosis of MS?
Andrew Solomon, University of Vermont
3:20 - 3:45pm Panel Discussion
3:45 - 4:00pm Break
4:00 - 5:30pm Cutting Edge Developments
Chair: Joan Goverman, University of Washington; Craig Moore, Memorial University
4:00 - 4:10pm Mass Spec Imaging of MS Lesion
Jennifer Gommerman, University of Toronto
4:10 - 4:20pm Flow Cytometry of Ex Vivo MS Brain
Tess Dhaeze, Prat Lab, Université de Montreal
4:20 - 4:30pm Nuclear RNAseq of MS Samples
Francisco Javier Quintana, Brigham and Women's Hospital
4:30 - 4:40pm Ground Breaking Abstract 1
4:40 - 4:50pm Ground Breaking Abstract 2
4:50 - 5:00pm Ground Breaking Abstract 3
5:00 - 5:10pm Ground Breaking Abstract 4
5:10 - 5:20pm Ground Breaking Abstract 5
5:20 - 5:30pm Ground Breaking Abstract 6
5:30 - 6:30pm Awards Reception
6:45 - 10:00pm Experience Dallas Dine Around
Experience Dallas as a local, from a local! This unique tour combines sightseeing and delicious food experiences into one fun-packed evening including a city bus tour and foodie excursion. Space for this tour is limited - registration is required. Transportation is included.

Saturday, March 2, 2019

6:30 - 7:45am An Interactive, Case-Based Discussion: Interpreting the Therapeutic Landscape in Multiple Sclerosis
This CME activity is provided by Physicians' Education Resource, LLC. This activity is jointly supported by educational grants from Sanofi Genzyme and Celgene Corporation.
8:30 - 9:50am SESSION 4 - MS Disease Course Endophenotypes
Chairs: Orhun H. Kantarci, Mayo Clinic; Helen Tremlett, University of British Columbia

Theme: There is significant heterogeneity in the MS disease course amongst patients. This session will discuss MS disease endophenotypes and associations with key demographic features.
8:00 - 8:10am Opening Comments by Session Chairs
8:10 - 8:30am Immunobiological and Radiological Markers of MS Endophenotypes
Roberta Magliozzi, University of Verona
8:30 - 8:50am Retinal Imaging for MS Diagnosis and Monitoring
Shiv Saidha, Johns Hopkins
8:50 - 9:10am Effect of Race and Ethnicity on MS Presentation and Disease Course
Lilyana Amezcua, University of Southern California
9:10 - 9:30am Role of Comorbidities in the Course of MS: Diagnostic and Treatment Implications
Ruth Ann Marrie, University of Manitoba
9:30 - 9:50am Panel Discussion
9:50 - 10:05am Break
10:05 - 11:50am SESSION 5 - Biomarker Measures of MS Disease Course
Chairs: Sergio Baranzini, University of California, San Francisco; Anne Cross, Washington University in St. Louis

Theme: Biomarkers which correlate or predict MS disease course may be of value in guiding management. This session will review emerging biomarkers and novel technologies applicable to MS.
10:05 - 10:15am Opening Comments by Session Chairs
10:15 - 10:40am Role of NFL and Other Biomarkers in MS Diagnosis and Disease Course
Jens Kuhle
10:40 - 11:05am Metabolomic Profiling in MS
Pavan Bhargava, Johns Hopkins
11:05 - 11:30am miRNA and Exosome Profiling in MS
Marcin Mycko, University of Lodz
11:30 - 11:50am Panel Discussion
11:50am - 1:05pm Lunch
11:50am - 1:05pm Advanced Strategies to Improve Outcomes and Reduce Disability in Patients with Multiple Sclerosis
This CME activity is provided by AcademicCME. This activity is supported by an educational grant from Novartis Pharmaceuticals.
1:05 - 2:55pm SESSION 6 - Algorithms Informing Precision Management of MS
Chairs: Xavier Montalban, University of Toronto; Jennifer Graves, University of California, San Francisco

Theme: Informed algorithms and predictors of optimized treatment and management can enhance patient outcomes. This session will discuss emerging technologies and algorithms to optimize MS patient management.
1:05 - 1:15pm Opening Comments by Session Chairs
1:15 - 1:35pm Applications of Network Science to Medical Challenges
Albert-Lazlo Barabasi, NorthEastern University
1:35 - 1:55pm Biosensors for Measuring Disease Activity in MS and Neurological Disorders
Dina Katabi, Massachusetts Institute of Technology
1:55 - 2:15pm How Can Large MRI Datasets Impact Precision Medicine in MS
Tal Arbel, McGill University
2:15 - 2:35pm Artificial Intelligence to Advance the Diagnosis and Treatment of Neurological Diseases
Ming Jack Po, Google
2:35 - 2:55pm Panel Discussion
2:55 - 3:05pm Closing Remarks
Jeffrey Cohen, Cleveland Clinic
3:15 - 4:30pm Industry Supported Satellite Symposium